When dealing with mycotoxin exposure, especially high levels of Zearalenone as revealed by tests like those from Great Plains, it is crucial to adopt a comprehensive detox plan. Zearalenone is a mycotoxin produced by mold that can disrupt hormonal balance and trigger symptoms associated with mold toxicity, MCAS (mast cell activation syndrome), and histamine intolerance. Incorporating supplements such as resveratrol and lycopene is often recommended due to their antioxidant properties and ability to support liver detoxification. Resveratrol can help reduce inflammation and protect cells from oxidative damage, while lycopene assists in neutralizing free radicals, enhancing overall detox effects. Gastrointestinal detoxification is equally important since the gut plays a central role in eliminating toxins. Supplements like activated charcoal, bentonite clay, or specialized GI detox formulas can bind mycotoxins in the digestive tract, preventing reabsorption. Additionally, supporting gut health with probiotics and a nutrient-dense diet can improve barrier function and further reduce toxin load. Managing symptoms related to MCAS and histamine sensitivity involves avoiding triggers such as mold-contaminated environments and histamine-rich foods. A low-histamine diet combined with antihistamine strategies may provide relief. It is also beneficial to consult with healthcare providers experienced in mycotoxin illness to tailor treatments effectively. Finally, reducing environmental mold exposure by improving air quality and remediating mold-infested areas is essential to prevent ongoing toxin accumulation. This holistic approach—combining targeted supplements, gut health focus, symptom management, and environmental control—helps restore balance and supports recovery from Zearalenone mycotoxin toxicity.