2025/12/1 Edited to

... Read moreBiliary atresia is a rare but serious condition that affects newborns, where the bile ducts outside or inside the liver do not develop normally. This obstruction causes bile to become trapped inside the liver, leading to liver damage and eventually liver failure if untreated. Early detection is crucial for improving outcomes. Parents and caregivers should watch for several warning signs in infants. Persistent jaundice beyond two weeks of age is a major symptom, especially if the infant’s stools are pale, gray, or white and the urine appears dark. An enlarged liver and poor weight gain may also be observed. Additionally, symptoms like irritability, distended belly, easy bruising, and vitamin deficiencies (especially fat-soluble vitamins D, E, K, and A) can indicate progression of the disease. If any of these signs are present, consulting a pediatrician promptly is critical. Diagnostic workup often starts with blood tests including direct (conjugated) bilirubin, total bilirubin, AST, ALT, GGT (which tends to be very elevated in biliary atresia), alkaline phosphatase, albumin, and clotting profiles such as PT/INR. Direct bilirubin levels over 1 mg/dL or over 20% of total bilirubin strongly suggest a concerning pathology. Imaging such as abdominal ultrasound can provide clues by showing a small or absent gallbladder, the “triangular cord sign,” enlarged liver or spleen, and helps rule out other causes of cholestasis but cannot diagnose biliary atresia on its own. A highly informative test is the HIDA scan, which assesses bile flow from the liver to the intestine. In biliary atresia, the tracer dye fails to move into the intestines even after phenobarbital stimulation, indicating blocked bile ducts. For definitive diagnosis, surgeons perform an intraoperative cholangiogram where dye is directly injected into the bile ducts. The absence of dye flow confirms biliary atresia. Many infants then immediately undergo a Kasai procedure during the same surgery to restore bile flow and delay liver damage. Awareness about biliary atresia is vital since early diagnosis and treatment, including liver transplant if needed, can vastly improve a child’s prognosis. Sharing knowledge about this disease helps families seek timely medical care and supports the journey of many biliary atresia warriors fighting for their health.