I've been through the challenging phase of dealing with extremely dry skin while on Accutane, and I understand how uncomfortable it can get. One crucial thing I learned is to avoid harsh soaps, like dish soap or hand soap, as they can strip your skin of natural oils and worsen dryness. Instead, opting for gentle, moisturizing body washes specifically designed for sensitive skin can make a huge difference. Also, regularly applying a good, fragrance-free lotion helps maintain skin moisture. It doesn't have to be anything fancy; just something that locks in hydration. I used to be inconsistent with moisturizing, but once I committed to it daily, the dryness significantly reduced. If you forget to apply lotion, even using simple oils like jojoba or coconut oil can help soothe tightness and flakiness. Additionally, limiting hot showers and avoiding scrubbing your skin harshly prevent further irritation. These little changes collectively improved my skin's feel and appearance during treatment. Remember, managing dry skin during Accutane is all about gentle care and consistent hydration. Listening to your skin's needs while on such medications can make the whole process more bearable and effective.