Many undergoing IVF often hear about the stimulation phase but rarely discuss the daily intramuscular progesterone in oil (PIO) shots that are crucial yet painful. Injected deeply into the buttocks with a 2-inch needle, this process can leave the area sore and bruised, making daily life uncomfortable. From my experience, the continuous poking becomes a mental and physical hurdle. The soreness is compounded by swelling and occasional redness, which can make sitting or lying down a challenge. Finding the right injection technique and rotating the injection sites helps alleviate some of the pain, but it doesn’t fully eliminate the discomfort. Support from partners or nurses during injections can significantly ease anxiety, turning the process into a routine rather than a dreaded event. Using warm compresses after the shot or light massage can help reduce inflammation and promote healing around injection sites. Despite the difficulty, this daily commitment is a hopeful step towards a successful IVF outcome. Knowing that the end of these injections is near can provide motivation to endure the temporary discomfort. Sharing these real-life challenges helps others prepare mentally and physically for this demanding phase of IVF treatment. If you’re about to start your PIO shots, remember to be gentle with yourself and seek support. Many find that talking about these side effects openly lessens the isolation of the journey. #ivfbaby #ivfjourney #fertility #PIO #ivfstory