🚨Eat anti-cancer drugs, "this group of fruits," absolutely do not eat!

👉, autumn, winter is the season when grapefruit is on the market, firm and juicy, sweet and sour, pleasing to many people, but for patients who are taking anticancer drugs such as targeted anticancer drugs.

👉 Grapefruit that looks like an ordinary fruit may become a safety risk in drug use include grapefruit, Ozatian grapefruit, red grapefruit, and other grapefruit family fruits.

It can react with ✅ drugs and can lead to life-threatening. 😱

Why is grapefruit "at odds" with anticancer drugs? 🤔

Behind it is a very important scientific mechanism.

👉 grapefruit fruits (especially grapefruit) contain a substance called Furanocoumarins, which can severely inhibit the CYP3A4 enzyme in the body.

The CYP3A4 enzyme is responsible for metabolizing and eliminating more than 50% of all drugs in the body.

Including a lot of anti-cancer drugs. ✅

When this enzyme is inhibited, 😱

👉 The drugs cannot be broken down and expelled normally.

👉 blood drug levels may increase several times or more.

👉 resulted in severe drug poisoning.

The most affected anticancer drug group 🔴

1 Targeted Therapy - Highest Risk 😱

Most orally aimed drugs rely on CYP3A4 for metabolism.

✅ Breast cancer: Palbociclib, Abemaciclib, Ribociclib, Lapatinib

✅ Lung cancer: Osimertinib, Erlotinib, Gefitinib, Crizotinib

✅ lymphoma / leukemia: Ibrutinib, Zanubrutinib

✅ Multiple cancers: Sunitinib, Apatinib, Sorafenib, Imatinib.

2 Chemotherapy drugs

Some chemotherapy drugs rely on CYP3A4 to metabolize or convert to drug activity.

Eating grapefruit can cause drug effects to change or increase poisoning.

✅ The Vinca Alkaloid Group: Vincristine, Vinca Allbean

✅ Taxen Group: Dosi Taxel

✅ Other: ethoposide, cyclophosphamide.

3 Antibody-Welding Medicine (ADC)

Even given intravenously.

But when a small toxin is released, it still relies on CYP3A4 to metabolize it.

➡️. Avoid, too.

4 Immunosuppressant drugs

Frequently used in bone marrow transplant patients or supplementary treatments.

Blood drug levels must be strictly controlled.

✅ Cychosporin.

✅ Tacrolimus.

✅ Sirolimus.

👉 Enzyme inhibition can cause drug levels to exceed and cause severe poisoning.

A misunderstanding to avoid. 🤔

❌ Myth 1: Do not just grapefruit anything else to eat?

Not true! Even grapefruit has the strongest effect.

But the Ozatian grapefruit, the red grapefruit, the bitter orange (Seville orange), the green lemon, the gooseberry.

There's furanocumarin, too.

👉 for safety should be avoided entirely during drug use.

❌ Myth 2: Just leave time to eat?

Not really!

Inhibition of CYP3A4 from grapefruit is permanent to the enzyme.

After taking grapefruit, it takes 24 to 72 hours for the body to create a new enzyme.

👉 even if you eat grapefruit in the morning, even if you take it in the evening, you're at risk of drug poisoning.

❌ Myth 3: Eat a little, okay?

Jeopardy!

Excessive drug levels can cause

🔴 Severe bone marrow pressure (leukocytes / platelets drastically reduced)

🔴 arrhythmia.

🔴. Liver and kidney damage.

🔴 Severe diarrhea.

All of these are real drug poisons in the clinic.

Safe edible fruit. ✨

No need to abstain from all fruits.

The following fruits. There is no or very little furanocumarin.

No reaction to anticancer drugs can be taken safely.

✅ Apple.

✅ grapes

✅ bananas

✅ Kiwi.

✅ barrow.

✅ common sweet oranges, such as Navel oranges.

# Cancer # Anticancer drugs # Aimed drugs # Cancer and fruit # FUDA Cancer Hospital