Triptans are a primary class of medications used specifically to treat migraine headaches by targeting serotonin receptors in the brain, which help to reduce inflammation and constrict blood vessels, relieving headache pain and related symptoms. Among these, Naratriptan tablets, typically dosed at 2.5 mg, are widely prescribed for their effectiveness and favorable side effect profile. The OCR recognized several brands and formulations including Naratriptan Tablets USP, Frovatriptan Succinate Tablets 2.5 mg, Sumatriptan tablets, Rizatriptan Benzoate tablets 10 mg, and Relpax (Eletriptan), all of which hold prominent positions in migraine medication rankings. Naratriptan is known for its longer half-life compared to other triptans, making it suitable for migraine attacks that require extended relief. Frovatriptan also benefits from a long duration of action and is often recommended for menstrual migraines. Sumatriptan was one of the first triptans developed and remains a mainstay due to its rapid onset of action, available in oral, nasal spray, and injectable forms for versatile use. Rizatriptan is favored for its rapid absorption and efficacy for acute migraine treatment. Eletriptan (Relpax) provides another potent option, often prescribed for moderate to severe migraine attacks. It is important to use these medications under medical supervision because they can have contraindications with certain cardiovascular conditions and other medicines. Dosing information and patient leaflets, as mentioned in the pharmacist’s instruction, help ensure safe and effective use. Patients should also be aware of potential side effects such as dizziness, fatigue, or chest tightness, and should report any unusual symptoms promptly. In addition to medication, managing migraine may include lifestyle changes such as stress management, adequate hydration, sleep regulation, and avoidance of known triggers. Combining pharmacological and non-pharmacological approaches enhances overall migraine control and quality of life. This comprehensive ranking and overview of triptans supports patients and healthcare providers in selecting the most appropriate therapy tailored to individual needs.