Insulin and GLP-1 receptor agonists

Insulin Learning Last 🫡

We summarize the combination drugs of GLP-1 receptor agonists and insulin.

I have the impression that GLP-1 receptor agonists have come to be used frequently in recent years, but how does it work when combined with insulin?

First of all, the big difference between insulin and combination drugs is indications for type 1 diabetes.

GLP-1 is a drug that stimulates insulin secretion, so it cannot be expected to be effective in type 1 diabetes mellitus where insulin is insufficient in the first place.

Side effects such as digestive symptoms are also a concern.

On the other hand, it is characteristic that it is difficult to become low blood sugar and that you can expect weight loss.

have similar characteristics

Let's compare "ultra-fast-acting type + long-acting type insulin" and "GLP-1 receptor agonist + long-acting type insulin."

From Novo Nordisk,

· "Rizodeg" (super fast-acting type + sustained-acting type)

Zoltophy (GLP-1 receptor agonist + long-acting)

are sold. Be careful not to mix them up because they look very similar.

As a difference in action,

In Rizodeg, ultra-fast-acting insulin acts as additional insulin.

In "Zolfi," GLP-1 receptor agonists play that role.

· "Lyzodegu" is a combination of insulin, so of course it can also be used for type 1 diabetes. In addition to once a day, it can also be used twice a day just before meals in the morning and evening. Therefore, while it is easy to control high blood sugar by meals, it can not correspond to lunch, so if necessary, an additional super fast-acting type is required.

Since "Zortofi" can be used at the same timing regardless of meals, it has the advantage of being easy to schedule, such as when administered by a caregiver.

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That was pharmacist Noriko (• ᴗ • و (و "

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