Mastering IV and medication administration is a critical competency for nursing students and practicing nurses alike. This cheat sheet provides a detailed guide that encompasses a wide array of techniques including Peripheral IV insertion, Heparin/saline flushing, priming IV lines, and handling IV piggybacks and IV push medications. Understanding the steps and precautions of each route enhances patient safety and care quality. Peripheral IV insertion is often the first skill nursing students learn, involving careful vein selection and knowledge of catheter sizes such as 16 gauge. Proper flushing with heparin or saline is essential to maintain line patency and prevent clot formation. Additionally, techniques like subcutaneous injections (often used for insulin or heparin), intramuscular injections including the Z-track method (for minimizing tissue irritation), and intravenous push medication administration require meticulous attention to dosing, site preparation, and infection control. Specialized skills in managing central lines like PICC (Peripherally Inserted Central Catheter) and CVC (Central Venous Catheter) are also covered, including dressing changes and blood draws. These invasive devices need conscientious care to prevent complications such as infections, thrombosis, or dislodgement. Moreover, the cheat sheet includes guidance on the administration of topical, transdermal, rectal, and vaginal medications, broadening the scope of medication routes students must be comfortable with during clinical practice. Incorporating this comprehensive checklist as part of clinical preparation can greatly improve proficiency and confidence. For nursing students studying for the NCLEX, such structured, visual aids not only reinforce theoretical knowledge but also assist in memorizing critical procedures and safety checks. Integrating these skills effectively ensures better patient outcomes and builds a solid foundation for future nursing responsibilities in medication administration and IV therapy.