MCAS (mast cell activation syndrome) and histamine intolerance are often used interchangeably because they both involve mast cells and histamine but they are actually 2 different things.
Both have to do with an excess of histamine but MCAS is much more complex and broader than just too much histamine.
Histamine intolerance has to do with our bodies not being able to clear out histamine which causes an excess whereas MCAS is when our mast cells create too much histamine as well as other mediators that can cause a host of issues.
The symptoms can look similar but people who have MCAS usually have more triggers that are more varied.
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