In my experience combining tretinoin cream and azelaic acid can bring noticeable improvements in skin texture and clarity. These products target different problems, with tretinoin boosting cell turnover and azelaic acid helping fade pigmentation and calm inflammation. However, starting both together requires patience as skin purging—temporary redness or flakiness—is common. To minimize irritation, I begin with applying azelaic acid gel 15% in the morning and tretinoin cream 0.05% at night, about two to three times per week. Gradually increasing usage allows the skin to adapt. Consistent use of a broad-spectrum sunscreen is essential because both ingredients can increase sun sensitivity and damage risk. Marsoo and sunscreen combinations are important steps in a daily routine. Additionally, I avoid layering other potentially irritating products during this adjustment phase. Combining these with supportive skincare such as gentle cleansers and moisturizers can soothe the skin. I also found that addressing underlying health issues like thyroid balance, cholesterol levels, and type 2 diabetes can indirectly improve skin condition. Good overall health supports skin healing while managing conditions like PCOS or fatty liver. For anyone dealing with skin damage, acne, or pigmentation, a carefully planned regimen involving tretinoin and azelaic acid provides an effective solution. Patience and sunscreen protection, alongside monitoring any side effects such as anxiety or acid reflux triggered by some medications, enhance long-term benefits.