Jordan | Genetic Counselor

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What does a negative test really mean?

Getting a negative genetic test result is not always the same as clinical clearance. Many genetic tests you can buy online test a small, curated panel. Not your full gene sequence and not the variants most relevant to your specific family history or ancestry.

For patients with a meaningful family history, a negative result can be a dangerous false sense of security.

A genetic counselor can help you understand not just what the test found, but also what it was designed (and not designed) to find.

#geneticcounselor #genetictesting #brca

3/12 Edited to

From personal experience, it's critical to understand that not all genetic tests are created equal. Online genetic tests often target a limited number of gene variants, which might overlook important mutations connected to your family history or ancestry. For example, a standard online BRCA panel might only test a fraction of the known variants, leaving significant risk undetected. I once had a friend with a strong history of breast cancer who received a negative result from an online test. Trusting this result gave her false security, but later clinical genetic testing identified a pathogenic BRCA2 variant, significantly impacting her treatment plan and surveillance. This highlights that clinical-grade genetic testing is more comprehensive and tailored to your personal and family health background. A key takeaway is the value of consulting a genetic counselor. They can interpret what your specific test covered and what might have been missed, considering your ancestry and family history. They can also help you understand the limitations of the test and discuss further testing options if necessary. Moreover, a negative result doesn't always mean no risk—it means no risk was found in the tested regions. So if your family has a strong history of certain diseases, a negative genetic test shouldn’t replace regular screenings or lifestyle considerations. In conclusion, use genetic testing as a tool, but always complement it with professional guidance and a comprehensive approach to your health care.

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