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Good teeth really calm rheumatoid?

2025/10/7 Edited to

... Read moreหลายคนอาจไม่ทราบว่าปัญหาสุขภาพช่องปาก เช่น ฟันผุและเหงือกอักเสบ มีผลกระทบถึงโรคภูมิคุ้มกันตัวเองอย่างรูมาตอยด์ได้อย่างไร โดยจากงานวิจัยหลายชิ้นยืนยันว่าแบคทีเรียชนิด Porphyromonas gingivalis (Pg) ที่พบในช่องปากสามารถกระตุ้นให้เกิดการอักเสบในเนื้อเยื่อและข้อต่อ ซึ่งเป็นลักษณะสำคัญของโรครูมาตอยด์ แบคทีเรีย Pg สามารถผลิตเอนไซม์ที่เรียกว่า peptidyl-arginine deiminase (PPAD) ซึ่งมีบทบาทในการเปลี่ยนแปลงโปรตีนในร่างกาย (citrullination) ทำให้ระบบภูมิคุ้มกันเข้าใจผิดว่าเป็นสิ่งแปลกปลอม ส่งผลให้เกิดการสร้างแอนติบอดีต่อโปรตีนที่เปลี่ยนแปลงเหล่านี้ เช่น anti-CCP ที่เกี่ยวข้องกับความรุนแรงของรูมาตอยด์ งานวิจัยยังพบ DNA ของแบคทีเรีย Pg ในเนื้อเยื่อข้อต่อของผู้ป่วยรูมาตอยด์ โดยเฉพาะผู้ที่มีอาการรุนแรง ซึ่งชี้ให้เห็นถึงการมีส่วนร่วมของแบคทีเรียนี้ในการกระตุ้นการอักเสบและทำให้อาการรูมาตอยด์กำเริบ ความสำคัญของการดูแลสุขภาพช่องปาก เช่น การแปรงฟันอย่างน้อยวันละ 2 ครั้งและรักษาโรคเหงือกอักเสบ จึงมีผลโดยตรงต่อการลดระดับการอักเสบในร่างกาย ในผู้ป่วยรูมาตอยด์ที่ได้รับการรักษาโรคเหงือกอักเสบมักมีอาการของรูมาตอยด์ดีขึ้น ค่าการอักเสบ (เช่น CRP) ลดลง และตอบสนองต่อการรักษาโรคข้อได้ดีขึ้น ดังนั้น การรักษาและป้องกันฟันผุ เหงือกอักเสบจึงไม่เพียงช่วยรักษาสุขภาพช่องปาก แต่ยังเป็นส่วนหนึ่งของแผนการดูแลและควบคุมโรครูมาตอยด์อย่างมีประสิทธิภาพ หากคุณเป็นผู้ป่วยรูมาตอยด์หรือมีความเสี่ยง ควรใส่ใจสุขภาพช่องปากและปรึกษาทันตแพทย์ร่วมกับแพทย์ผู้ดูแลโรคภูมิคุ้มกันเพื่อผลลัพธ์ที่ดีที่สุด

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