Chronic acne, poor sleep, weight gain... maybe the cause is the "intestines."

Gut Microbiome: A secret population in the gut that oversees virtually every system in the body.

By Professor Pisit, the Kong Samut family

You know, in our gut, there are over 100 trillion "microbial communities" living!

They are not passive, but they are "behind-the-scenes armies" that control from clear skin or pimples, sleep or nightmares, firmware or fat belly puppets, and even "joy or sadness in the mind."

Imagine that...The gut is "kingdom."

🦠 Good microbes = virtuous citizens, acting like doctors, teachers.

💣 Malignant microbes = mobs that create chaos, destroy immunity, cause acne, intestinal inflammation and mood swings.

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💡 Gut Microbiome?

Gut microbiome = microbial ecosystem located in our gut (consisting of bacteria, fungi, viruses, both good and bad types)

The main function of the Gut microbiome is not only to help digestion, as it once understood, but to control virtually all systems of the body.

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🧖‍♀️ Gut-Skin Axis (Gut-Skin Skin; Acne & Skin Allergy Rash)

Leaky Gut → Vulnerable intestinal wall causing endotoxin to enter the bloodstream → Inflammatory throughout the body

Some fine microbes (Lactobacillus rhamnosus) reduce acne and skin allergies (atopic dermatitis) (1).

There is a connection between Gut-Skin Axis and chronic acne and seborrheic dermatitis (2).

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🧠 Gut-Brain Axis (Gut-Brain; Mental Health & Sleep)

The gut generates serotonin (Serotonin = the neurotransmitter of happiness) to 90% of the total in the body (3).

Some microbes produce GABA (Gamma-aminobutyric acid) → helps calm, reduce stress and sleep better (4).

Dysbiosis (dysbiosis = intestinal microbial balance damage) has been linked to depression and anxiety disorders (5).

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❤️ Gut-Metabolic Axis (Gut-Heart; Sugar & Fat)

Some microbes control blood lipids and prevent insulin resistance (6).

But some strains are linked to the production of TMAO ().

Red meat → Microbes converted to TMA (Trimethylamine) → Liver converted to TMAO

High TMAO → Increased cardiovascular risk (7)

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💩 Gut-Immune Axis (Gut-Immune System)

The intestine is home to 70% of the body's immune system (8).

The intestinal lining contains GALT (Gut-Associated Lymphoid Tissue = lymphoid tissue of the intestine), acting as the "first line of defense" of immunity.

Good microbes, such as Lactobacillus, Bifidobacterium.

Activate Treg cells (Regulatory T cells = leukocytes control inflammation)

Increased IgA production (Immunoglobulin A = anti-lining antibody)

Reduce the leakage of endotoxin (LPS) into the blood.

Children with little variety of microbes → high allergy risk (9)

Dysbiosis is linked to autoimmune diseases such as rheumatoid, SLE, Multiple Sclerosis.

Research has shown that some strains of probiotics (Lactobacillus casei, Bifidobacterium infantis) improve immunity and reduce the severity of inflammation.

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🫁 Gut-Lung Axis (bowel-lung; respiratory disease)

Gut microbes directly affect lung immunity (12)

Dysbiosis is linked to asthma, respiratory allergy.

Recent research has shown that the microbiome affects the severity of lung infections, including COVID-19.

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🏵️ Gut-Liver Axis (Gut-Liver)

Condition Leaky bowel → endotoxin (LPS = lipopolysaccharide) slips into liver → stimulates inflammation

It is directly linked to NAFLD, hepatitis, cirrhosis (13).

SCFAs (short-chain fatty acids) from microorganisms help reduce inflammation and stimulate fat metabolism in the liver.

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💜 Gut-Reproductive Axis (Gut-Reproductive System)

Gut microbiome affects sex hormone balance through Estrobolome regulation (a group of microorganisms with respect to estrogen metabolism).

Dysbiosis has been linked to PCOS (multiple ovarian cyst), endometriosis (misplaced endometriosis), infertility.

There is evidence that a balanced microbiome enhances fertility, and reduces gynecological disease risk (14).

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🚨 What destroys microbes?

- Excessive use of antibiotics

- Processed food (Ultra-processed food)

- High sugar.

- Chronic stress.

- Sleeping late.

- Lack of exercise

- Lack of dietary fiber and colorful vegetation.

📉 When a good microbial population disappears → the whole system.

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🌟 How to increase microbes is good.

1.Prebiotics (prebiotics = food of fine microbes) → e.g. raw bananas, oats, garlic, onions, chicory, artichokes

2.Probiotics (Probiotics = Good Microbial Body) → Such as Lactobacillus, Bifidobacterium (in Yogurt, Kimchi, Tempe, Natto, Michosa, Kombucha, Saukraut, Supplement)

3.Postbiotics (postbiotics = good microbial by-products) → short-chain fat crows (short chain fatty acids; SCFAs) such as Butyrate → help reduce inflammation (10)

4.Parabiotics (Parabiotics = Dead but still active microbes) → Immune stimulation, reducing inflammation (11)

✅ can Postbiotics / Parabiotics enhance microbes?

Help "indirectly" by:

Balancing the gut → fits the microbial boom well.

Reduce intestinal inflammation.

Immune stimulation (via TLR receptors = Toll-like receptors)

🔍 How to choose Probiotics

Select multi-strains (multiple species) + have supporting research.

Quantity of ≥ 20 billion CFU (Colony-forming units)

Select formulas with prebiotics.

🔑 Conclusion:

Gut = All-in-one Health Control Center

Want clear skin, calm heart, good sleep, shapely, good mood, reduced allergy → Start with the care of the gut microbes 🌈, good health is the care of the "good little microbes in our gut."